The word "angioedema" can also refer to allergic responses.

In this case the chemical targeted is histamine. Gabapentin and Lyrica have allergic potential...and it can occur at any time in therapy.

The second type of angioedema is NOT histamine mediated, but the chemical is bradykinin. This type does not respond to antihistamines, H2 blockers or prednisone, or epinephrine (although doctors will give the epinephrine anyway during airway events).

Here is a paper that explains bradykinin:
http://www.ncbi.nlm.nih.gov/pubmed/17620062

https://secure.muhealth.org/~ed/stud...les/Oct_08.pdf

This second article gives a long explanation on bradykinin.

As we spoke in our PMs, tkrik, I use one Lasix 40mg once a week or every other week, depending on the severity of my swelling. I have found this very helpful, as it takes time for the fluid to return to painful levels. Also my research found that bradykinin receptors can be somewhat blocked by bromelain, and green tea.
I use a special enteric coated bromelain to preserve it from stomach degradation. (it is made by LEF).

By keeping a journal, I can predict now swelling episodes. A day or two before they become severe, I have less urination in spite of drinking lots of water. If I don't take the Lasix then, it turns into a nasty episode, for me. However, most of my angioedema is GI still, with body swelling secondary.

If you are continuing on gabapentin, I'd suggest you taper off. This drug is notorious for causing swelling of the body, difficulty breathing and allergic responses.
http://www.drugcite.com/?q=gabapentin

You can continue to PM me anytime. This is a very difficult thing to diagnose and only the special blood tests reveal it. Find a doctor who can give and interpret these as soon as possible.

I was on a problematic drug (lisinopril) for almost 10 yrs before my massive angioedema attack. I consider myself very lucky to be here typing this post to you!