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Old 05-09-2013, 02:54 AM
Paul Brennan Paul Brennan is offline
Junior Member
 
Join Date: Jul 2011
Location: Sydney, Australia
Posts: 6
10 yr Member
Paul Brennan Paul Brennan is offline
Junior Member
 
Join Date: Jul 2011
Location: Sydney, Australia
Posts: 6
10 yr Member
Default Sirio (melevodopa/carbidopa)

Quote:
Originally Posted by johnt View Post
Quantifying the short term effect on me of Stalevo dispersed in ascorbic acid (Vitamin C).

My recipe was very simple:
- put one Stalevo pill (75mg levodopa) in a glass;
- add 50ml water;
- add 1000mg effervescent vitamin C tablet.
Leave for 2 hours to disperse.

John
Your dedication to detail is inspiring! Do you know of melevodopa (methyl ester of levodopa)? It is routinely used in Italy, produced by Chiesi Farmaceutici in Parma and called Sirio (a soluble form of L-dopa with carbidopa). In other words - fizzy Sinemet. It is reputed to cross the blood-brain barrier more rapidly than the standard formulation. Search pubmed.com using the keywords “Sirio” and “Parkinson’s Disease” for a couple of studies. The Italian website Unioni Parkinsoniani also has some information on Sirio. Google Translate can be used for a rough English translation. It’s not expensive but officially only available in Italy. Keep up the good work.
Paul
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