Sandy, Mestinon kicks in after about 20 - 30 minutes. It lasts for only about two hours after that. That's how the drug is.

There are two things you and your neuro can discuss: Raising the dose amount/mg. and increasing the dose frequency. More is not always better with Mestinon (meaning dose amount/mg.).

If you get too much acetylcholine in your body by taking too much Mestinon, you can have a cholinergic crisis.

If you don't get enough acetylcholine, it's called a myasthenic crisis.

Both make you weaker but the cause is different.

When you said "wean off completely soon," you meant the Pred, right? I was on Pred for a month after my MG crisis. It worked more quickly on the facial muscles but it took longer for the other, "larger" muscle groups.

It should help having the Pred only in the morning. I hope so.

Annie