Here is a link to information about the evidence for autoimmune activity in RSD/CRPS. To read it, just copy and paste it into your browser:

http://www.rsds.org/pdfsall/Blaes_An...20Sci_2007.pdf

I also have some anecdotal evidence. My daughter and I started receiveing 15 grams of Privogen brand Iv Ig every 4 weeks. Our doctor noticed the benefits and felt we could do better with a slightly higher dose every 21 days. So, we started getting 20 grams of Privogen brand Iv Ig every 21 days. After 6 months, both of us were immensely improved and off all medications. My 32 year old daughter had a severe, advanced case of MS (Multiple Sclerosis). She was in a wheel chair, could not see well enough to read or drive due to optic neuritis, and suffered from extreme neuropathic pain. Now, she is reading, driving, walking just fine and almost entirely pain free. I am 58 and have lived for 35 years with RSD/CRPS that had spread throughout my body. I'm now free of pain, dystonia, involuntary movements, cramping, discoloration, sweating, brain fog, etc. And, I'm off all the meds I once desperately needed for pain, cramping, and involuntary muscle twitching. No more Neurontin, Cymbalta, Methadone, and Klonopin!

I would like to see more specificity when people write or talk about Iv Ig therapy. Considering my experience, I know that the amount given and the time interval between infusions are important details. I imagine the amounts and time intervals could vary considerably between different individuals, depending upon the degree of autoimmunity involved. The immune boosting effects of Iv Ig infusion drop off rapidly after 2 weeks. Perhaps a 2 week interval would be best in the beginning. Perhaps some may be fine with a 3 week interval, etc. Also, I know that the type of Iv Ig formulation is important. For example, brands mixed with sucrose instead of saline are not safe. The doctor who does my Iv Ig infusions is an infectious disease specialist who has been doing Iv Ig infusions for over 20 years. He has stuck with Privogen, because he has never had a problem with it.

Two resources for more information about autoimmunity and RSD/CRPS are:

1. American Autoimmune Related Diseases Association on the web at www.aarda.org
2. Advocacy for Paitients on the web at www.advocacyforpatients.org

Good Luck To You! Good Healing!