I too think that CRPS has an auto-immune aspect to it. I'm curious, did any of you have courses of antibiotics prior to developing CRPS? I ask because my fiancee had several long courses of antibiotics when she was in her early 20s, after which point she started having gluten sensitivities she didn't have before, headaches, and eventually developed CRPS. I have a pet theory that compromised gut flora (which constitute a large portion of the immune system) can lead to maladaptive inflammatory processes, which lead to cortical (and perhaps other) changes in the brain that maintain pain. Just a pet theory I've kicked around (although an article out of Drexel last year found that folks with CRPS have significantly less diverse gut flora than their healthy counterparts).

Anyway, my fiancee has been on probiotics for about 3 months now and her sensitivity to gluten has drastically decreased. Furthermore, I believe that the probiotics have helped with her pain levels and immune response as well (although it's hard to tell as she has been doing several things that have all been helping). Also, she just started LDN about a month ago (which a lot of people use for autoimmune diseases) and has had great results in terms of consistency of lower pain and increase in stamina.

Just some scattered thoughts I had on the subject.