The maximum amount of mestinon, I was on was 90mg four times a day and 180 at night. I once double dosed by accident and felt no ill effects. In fact, I have never experienced any of the bad side effects from mestinon. My mestinon starts wearing off about 3 to 3.5 hours after dosing. I can always tell without looking at my watch, because I start to experience excessive sweating and weakness like i am going to faint. It reminds me it is almost time to take my mestinon.

kathie