Hi dorrie and sue thank you for spending the time to answer me,some of the meds i am on only for a short time, like a day others it takes a week, the insulins have taken till I have gotten over 10 units and then I start having the gastro and nausea, I have tryed metforman that was the first one they put me on that was bad,and diabex advandia now advandiamet see how that goes. will keep you posted and tank you again.