So far, the nerve pain seems to be quieting down alittle. Still have some but not nearly as bad. My appetite is pretty much gone. Im lucky if I eat one item a day, and drink one bottle of water a day. I have just lost all interest in eating and drinking. If I force fluids, I get nausea and vomit, so I dont force it any more. My tremors are getting worse, and my hand writing has gone from a 42yrs old to a 1st or 2nd graders. DH is panicing, me, Im like whatever, its just the MS. I talked to the pharmacist about the loss of appatite and not drinking and she said it was the topamax, so Im not real worried. Hey, maybe I;ll finally lose those extra pounds.. hehe!! (gotta find humor where I can folks!)