I take baclofen and tizanadine. I take one of each, together and they seem to usually work. Been on baclofen for about 2yrs and the other for almost a year. Alot of MSers say stretching exercises help with their spastisity, however for me stretching makes mine worse. Also, hot and/or cold packs can provide some relief. I have a muscle in my forearm that is permanently tight and I do on/off ice pack/heat pad and then meds and it helps. When dealing with MS spasms it can be a real hit and miss with how each individual finds relief.