There is a current national multi-center Phase II study ongoing for Pioglitazone. I met with a local participating research center a few months ago to see about participating. Unfortunately, the inclusion/exclusion criteria was limiting. You had to be on either rasagiline or selegiline for at least 8 weeks but not more than 8 months (which was perfect for me as I was on Azilect for 6 months at the time). Stable dosage anticholinergics are also allowed. However, no dopaminergic drugs or amantadine were allowed. I had started on amantadine so was excluded.

For any early stage PWP who are interested in this trial, go to MJFF Trial Finder, there are centers doing research all over the country.