I started on 40 mg of pregnisone and my doctor told me to take it in the morning. I did note that my MG symptoms had less fluctuation and all my muscle pains went away. I know that pregnisone can effect your mood but it had a positive effect on mine. I was more chipper and I actual caught myself singing. I had not sung in almost 2 years.

It did give me insomnia and big black and blue marks without having injured my limb. I am currently being weaned off pregnisone. The insomnia went away at about 25mg dose, but the muscle pains and badder days are working their way back in.

kathie