I find I can fly fine, while a good friend cannot fly but can drive.
There is hot RSD, and there is cold RSD.

So the point, is trying to figure out what her needs are.
I travel with homeopathic remedies that help, as well as clothing to keep my limbs covered, what my body needs.

If you can get you Mam to figure out what she will need, she will be fine.
It is too depressing to get left behind or to cancel a trip.

My husband's family lives 2 states away so he drives. I fly and meet up with him. A hassle, but I miss a major flare up from the road vibration!