Thank you for these, Heat Intolerant. I haven't finished reading but I did find this interesting.

"...In the case of exogenous ligand, modulation
of receptor numbers is considered
to be an important determinant
in the development of
drug tolerance, and may also contribute
to the withdrawal syndrome
that frequently accompanies
cessation of drug usage .

I've said for years, sometimes, I need a medical dictionary on my desk for
quit reference so I'm not back and forth on the Net!