Thanks gaykir. My wife has had 4 dbs surgeries, with the best result being it alleviated her tremor on her right side. It was pretty severe so that was a major blessing. Unfortunately her medication doesn't always kick in and she needs something to take over until the sinemet takes effect. She was never really able to reduce her medication after the dbs but we're still hoping that her latest surgery will help more on that. Meanwhile, we're hoping Apokyn will help fill in the gap. Thanks again, Gary