Hello I'm not sure if this thread is still active but i'll take the chance it's not. A few months ago I was diagnosed with Pyroluria, my Pyrrole levels were 24.6 HPL(ug/dL) Normalised. The strange thing was my b6 P5P levels were exceptionally elevated at 280 nmol/L (35-110), before the test i had never taken b6 supplements. My zinc levels were at the low end at 10.6 umol/L (9-19). I feel I have symptoms of peripheral neuropathy, I now have a constant tingling in my feet, and occasionally in my hands. I have transient numbness in areas of my feet, along with seldom transient pin prick sensations in my feet, hands, arms, and legs.
I understand elevated pyridoxine levels are caused by the inability of the liver to convert it to P5P, but I don't have elevated levels of pyridoxine, I have elevated levels of P5P. Can elevated levels of P5P cause PN? What can cause elevated levels of P5P if you have never supplemented with b6?
Any feedback would be much appreciated.

Thanks.