I also found a mention about GABA and the pancreas. This I didn't know about, and will look into more in the near future.

I notice when I take the GABA regularly (I don't always take it every day)... I don't have much appetite and I am losing some needed weight. So I found that GABA works on the islets in the pancreas to moderate insulin. I'll be searching on that soon, in more detail...but it seems to work that way with me at least, so I am pleased. I am also less stiff and achy, which plagues me sometimes, and my dreams have changed to more benign subjects and the nightmares have stopped.

So all the major benefits I have so far are mostly in the body, and mild brain effects. It doesn't bother me that GABA is not well crossing the blood brain barrier therefore, because these other effects are very helpful for me. (as people age, the BBB does become a bit more permeable, so older people using PharmaGABA may see more central brain effects than younger ones.).

Hubby certainly is less grumpy this week, and he is only on 100mg at bedtime. So I can see this improvement in his behavior quite easily!