I have to agree that I think your dosage may be low on both your meds. I started pregnisone at 40 mg a day and have currently been weaned down to 25. I take 60 mg of mestinon 4 times a day and 180 mg time release at night. I find if I miss a dose, I feel very bad and it takes time to recover. That I am much better at a constant therapeutic dose. Mestinon is very short acting and it starts to wear off on me in about 3.5 hours.

My symptoms had been getting progressively worse, so I just finished a 5 day course of IVIG. I found it rather grueling but I am seeing improvement in my MG symptoms.

kathie