Thank you for the information Mrs. D. I took 300mg of Benfotiamine this morning (I had only been taking 150g) and within 5 minutes my face was burning and bright red, I can only assume it was that as yesterday I just took the smaller dose of all the supplements and was fine and that is the only thing I did differently. Hopefully it will go away soon and I think I will take them as two x 150mg rather than 300mg all in one go in the future.