I don't know about the other substances, Rick, but all the years I took selegiline I felt great as far as its effects on my PD symptons, plus it had a more "natural feel" to it than any other PD med. It has anti-depressant properties, HOWEVER, I had continuous migraines that could last from 3 to to 20 days and I also developed a nasty cough that got worse and worse, especially in bed, and nobody was getting a decent night's sleep anymore. If only somebody could extract the beneficial ingredients only!