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Old 06-25-2013, 03:57 PM
johnt johnt is offline
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Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
johnt johnt is offline
Senior Member
 
Join Date: Apr 2009
Location: Stafford, UK
Posts: 1,059
15 yr Member
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soccertese,

You mention that levodopa works well "until about noon" and "repeat the cycle with sleep fixing the problem".

IMHO this strong diurnal relationship suggests that melatonin may be playing a part in your problem.

"Melatonin ... is a naturally occurring compound found in animals, plants, and microbes.... In animals, circulating levels of the hormone melatonin vary in a daily cycle, thereby allowing the entrainment of the circadian rhythms of several biological functions." [1]

"In patients with Parkinson's disease (PD), MT1 and MT2 expression declines especially in the substantia nigra and the amygdala." [2]

Hardeland [2] lists a wide range of symptoms.

References

[1] http://en.wikipedia.org/wiki/Melatonin

[2] "Neurobiology, Pathophysiology, and Treatment of Melatonin Deficiency and Dysfunction"
Rüdiger Hardeland
ScientificWorldJournal. 2012; 2012: 640389
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3354573/

John
__________________
Born 1955. Diagnosed PD 2005.
Meds 2010-Nov 2016: Stalevo(75 mg) x 4, ropinirole xl 16 mg, rasagiline 1 mg
Current meds: Stalevo(75 mg) x 5, ropinirole xl 8 mg, rasagiline 1 mg
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