I've been on both drugs, Lyrica first, then I swapped to Neurontin because my docs thought it a good idea (suspect cost was a big factor), now I'm back on Lyrica again.

I know it does work for some people, but the Neurontin did not touch my pain in my foot, in fact my pain levels got progressively worse while I was taking it (max was 600mg morning and afternoon, 900 mg at night). I also had two nasty bouts of GI pain, nausea and vomiting - the first time, my GP thought it was a stomach bug (nobody else got it!), the second time they were more concerned. I noticed no difference in my CRPS pain levels during the 3 days I couldn't keep the tablets down, so I gradually titrated off the Neurontin. I felt so much better after coming off it that to be honest I wouldn't go back. My pain doc said my GI problems with it 'weren't uncommon' and it was 'powerful stuff'.

Going back on the Lyrica I noticed the pain difference really quickly - It doesn't stop the pain, but has taken away the worst of the knife-like stabs, and my stomach is doing ok again. To be fair, I am a coeliac (no gluten, quite common with CRPS patients) and I cannot tolerate ibuprofen, so maybe my stomach isn't as tough as some other folk!

Bram.