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Old 07-02-2013, 04:11 PM
Kitt Kitt is offline
Grand Magnate
 
Join Date: Aug 2006
Posts: 4,440
15 yr Member
Kitt Kitt is offline
Grand Magnate
 
Join Date: Aug 2006
Posts: 4,440
15 yr Member
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Quote:
Originally Posted by mrsD View Post
The literature currently has articles like this, demonstrating drugs or other things triggering CMT symptoms in otherwise asymptomatic patients:

http://www.ncbi.nlm.nih.gov/pubmed/8600343

http://www.ncbi.nlm.nih.gov/pubmed/11442172

http://www.help4cmt.com/articles/?id...scular-disease

Levaquin unmasking asymptomatic CMT:
http://www.theannals.com/content/45/10/1312

While environmental events do not CAUSE the genetic mutation itself, it seems that they can trigger symptoms, in people who don't know they have CMT until the event occurs. Some people live without knowing they have CMT because onset varies so much between patients.
The first site talks about Vincristine. It is one that a person with CMT should never ever have. It also does a number on some of the general population. A young man (non CMTer) in our town had it and it was awful and stopped. It is on the medications alert.

The third site talks about Allison Moore. I know of her. Her father had CMT and she inherited it from him. It was a combination of three drugs one being Vincristine that she took for cancer in her leg. This set it off for her. Had she known that you should not have Vincristine she might not be wearing AFO's today and CMT would not have progressed so rapidly in her case. She has said this herself in a video on CMT. There were signs of her body which should have been caught much sooner along with the family history. She had high arches (not everyone with CMT does) and she couldn't stand on her heels. This was much earlier in her life. The Vincristine did a number on her for sure.

We were told at one of our support group meetings by an expert neurologist who knows CMT that if we were given Vincristine we could end up just laying there and not be able to do anything much at all.

The fourth site is one I have read before. It talks about the "possibility". And this person had plenty of symptoms beforehand.

Not the environment, so to speak, it's the medications these people had that brought CMT to light even though there were other signs which apparently were not recognized at the time.

Last edited by Kitt; 07-02-2013 at 04:36 PM.
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"Thanks for this!" says:
Susanne C. (07-02-2013)