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Old 07-03-2013, 06:39 PM
jolot jolot is offline
Junior Member
 
Join Date: May 2009
Location: Canada
Posts: 10
15 yr Member
jolot jolot is offline
Junior Member
 
Join Date: May 2009
Location: Canada
Posts: 10
15 yr Member
Default weaning off sinemet

Probably not the correct procedure!
July 2013. I am a resident of Canada living alone in Edmonton, Alberta, age 74. I was diagnosed with PD in 2001 and have mild familial ET since my teens. My Neuro sent me to see a specialist in Vancouver in 2010 as he was confused about my diagnosis mainly because Sinemet had no effect. He confirmed the diagnosis as tremor intensive PD and said I would need to start on Sinemet at some point. Started on Prolopa eighteen months ago, now on Sinemet (150mg x 3/day) which only during the past several months causes severe pounding tremor in my right arm one to two hours after ingestion, causing continual freezing making it very difficult to stand up from sitting position, change direction, dress myself. exercise, etc and lasts for seven or eight hours. I can go without the med for a day with a big improvement but any longer I start to weaken. In the past several months I have gone from self-reliance to dependence. I am striving to find a balance by cutting back to 1 x 50 mg twice daily. Sinemet is definitely no longer helping my condition. Any suggestions?


Quote:
Originally Posted by I_Got_it_2 View Post
Has anyone tried to stop Sinemet (Carbidopa-Levodopa)? I'd be curious.

The following warning appears on the web:
-------------------------------------------
WARNING!
Do not stop taking Sinemet suddenly, as a serious group of side effects, known as neuroleptic malignant syndrome (NMS), may occur. Symptoms of NMS include:


•A high fever
•Stiff muscles
•Confusion
•Irregular pulse or blood pressure
•A fast heart rate (tachycardia)
•Sweating
•Irregular heart rhythms (arrhythmias)
-------------------------------------------


I stopped cold turkey 3 weeks ago and have had little negative reaction but absolutely no muscle stiffness. I can do little things now that were either impossible or very difficult: shaving, showering, driving, writing, getting out of a chair, typing, rolling over in bed.

Just wondering if others have had experiences they could share.

Jim
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