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Old 07-05-2013, 12:41 PM
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
soccertese soccertese is offline
Magnate
 
Join Date: Nov 2007
Posts: 2,531
15 yr Member
Default

OK,
i multiply the CR dose by 60% when calculating total l-dopa so your're taking maybe 500-600mg l-dopa, CR has less bioavailability than the immediate release - less gets into your blood than with IR. so logically would expect greater relief of your symptoms with more l-dopa which isn't happening. may CR which i believe dissolves and forms a gel which moves slower thru your intestine and supposedly lasts longer just doesn't work for you, it can take 2hrs to reach max. blood concentration so maybe you are getting too much l-dopa at times.

again, you need to pester your doctor for advice and i'll repeat my layman's theory that maybe you need to try another generic or even the brand name, not sure if SINEMET is still sold?

good luck.
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