I had some pretty awful "fireworks" at the crescendo of my toxic drug reaction to lisinopril. Now I have very few of these, and mostly they are in my left foot which has the complex scar and spurring in the ankle (as per my recent Xrays).

I think stress will do it, as I was having major stress with that drug reaction as well.

It is possible that once nerves are irritated by something, they remain on hyper vigilant alert and perhaps get set off with very little stimulus. Just 2 days ago, I had pain shooting in the sural nerve area of that ankle, and so I put on the mag lotion just over that part (which I tend to ignore because of its location). The zaps stopped within minutes! I have to wonder if the zaps are revealing micro-circulation issues in various tissues of the body.

Inflammation triggers the local release of cytokines, and they perhaps are the culprits. These chemicals are in all our cells, waiting for some trigger/signal to be released. They don't as a rule circulate far... and typically remain localized.

That new info regarding fibro, and nerve bundles in the palms, acting as signalers for circulation changes, intrigues me. Could be connected to PN perhaps?

cytokines and fibro pain:
http://neurotalk.psychcentral.com/post977893-47.html

nerves in palm and circulation changes:
http://psychcentral.com/news/2013/06...gia/56233.html