No one has any idea, at this time, if mannitol is neuroprotective in humans, no less what a proper dosage would be if it is. Even if it performs in humans like it did in fruit flies and mice (preventing and removing a-syn clumps) it may only slow or stop progression and not actually be curative. Therefore, it would be highly unlikely that you would notice any changes after just one week, if at all.

Good luck, keep us informed of your progress.

Gary