Title Lancet Seminar: Motor neurone disease (amyotrophic lateral sclerosis)

Date Published 15/06/2007
Reporter initials Devika
Reporter surname Sennik
Reporter affiliation Hospital Pharmacist
Source The Lancet 2007; 369:2031-2041
Resource Links Link to summary

Abstract The authors of this Seminar review the natural history, clinical features, diagnostic criteria, variant and mimic syndromes, genetic forms, and epidemiology of motor neurone disease (amyotrophic lateral sclerosis). They discuss disease-management strategies and review options for control of the main symptoms of this progressive neurodegenerative disease - including dysphagia, dysarthria, respiratory distress, pain, and psychological disorders - and care in the terminal phase. The following topics are discussed in the review:

• Natural history, clinical features, and epidemiology
• Diagnostic criteria, clinical rating scales, and quality-of-life measurement
• Causal and pathogenetic hypotheses
• Management
o Disease-modifying treatments
o Symptom control and palliative care
o Psychosocial care
o Spiritual care and bereavement
o Terminal phase
• Future prospects
• The way forward

Categories Medical Specialty > Neurology > Motor neurone disease

Medicines Information > Drug reviews

BNF Category > 4: Central nervous system > 4.9 Drugs used in parkinsonism and related disorders > 4.9.3 Drugs used in essential tremor, chorea, tics, and related disorders

http://www.nelm.nhs.uk/Record%20View...aspx?id=581844