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08-23-2007, 07:21 AM | #1 | |||
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In Remembrance
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Cognition and Amyotrophic Lateral Sclerosis (ALS)
D. Irwin, MD Drexel University College of Medicine, Philadelphia, Pennsylvania Carol F. Lippa, MD Drexel University College of Medicine, Philadelphia, Pennsylvania, clippa@drexelmed.edu J.M. Swearer, PhD University of Massachusetts Medical School, Worcester, Massachusetts Amyotrophic lateral sclerosis (ALS) is classically described as a pure motor disease; however, there is growing evidence of a range of cognitive impairment. Cognitive abnormalities include deficiencies in frontal executive skills, varying from mild deficits to meeting criteria for diagnosis of frontotemporal dementia (FTD). Cognitive impairment occurs in sporadic and familial forms of ALS. Patients may present with cognitive deficits before, after, or at the onset of motor neuron disease. Structural and functional imaging studies have shown extramotor cortical degeneration corresponding to levels of frontal executive impairment on neuropsychologic testing. In addition, ALS and a subset of FTD patients display common pathological findings on immunohistochemistry staining. It is believed that these disorders represent a continuum between motor and nonmotor cortical degeneration. The purpose of this article is to review the literature on cognitive deficits in ALS. Identifying changes in cognition is critical for physicians and caregivers of ALS patients, as cognitive decline may interfere with patient compliance. Diagnosis and treatment of cognitive symptoms in ALS patients may improve quality of life. Key Words: ALS dementia tau progranulin frontotemporal dementia cognition http://aja.sagepub.com/cgi/content/abstract/22/4/300
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. ALS/MND Registry . |
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