ALS News & Research For postings of news or research links and articles related to ALS


advertisement
Reply
 
Thread Tools Display Modes
Old 10-31-2007, 09:15 PM #1
BobbyB's Avatar
BobbyB BobbyB is offline
In Remembrance
 
Join Date: Aug 2006
Location: North Carolina
Posts: 4,609
15 yr Member
BobbyB BobbyB is offline
In Remembrance
BobbyB's Avatar
 
Join Date: Aug 2006
Location: North Carolina
Posts: 4,609
15 yr Member
Note Antibiotic accelerates tragic Lou Gehrig's disease, says study

Antibiotic accelerates tragic Lou Gehrig's disease, says study


PARIS (AFP) — An antibiotic tested on patients with Lou Gehrig's disease in the hope that it can slow this crippling disorder of the nervous system in fact worsens symptoms, a study released on Wednesday said.

The drug, minocycline, was tested on human volunteers with amyotrophic lateral sclerosis (ALS), as Lou Gehrig's is called, and doctors are testing it on several other diseases of the nervous system.

These trials were launched after tests on lab-dish cells and on mice engineered to have ALS symptoms suggested minocycline could inhibit inflammation and apoptosis -- the process by which nerve cells are ordered to commit suicide.

But in a study published by The Lancet Neurology, US researchers found that ALS patients who took minocycline deteriorated 25-percent faster than counterparts who took a dummy lookalike pill, called a placebo.

"Our finding that minocycline has a harmful effect on patients with ALS has implications for trials of minocycline with other neurological disorders, and for how potential neuroprotective agents are screened for us in patients with ALS," says the study, lead-authored by Paul Gordon of New York's Columbia University.

Minocycline is a second-generation, broad-spectrum member of the tetracycline family, used in a wide range of bacterial infections.

Lou Gehrig's is a currently incurable but also enigmatic disease. It occurs when nerve cells die out, leaving the brain less and less able to control muscles and leading ultimately to paralysis.

Only about 10 percent of patients have a known family history of ALS, which thus causes the finger of blame to point at environmental factors.

Gordon's team enrolled 412 ALS patients, who were randomly assigned to receive a placebo or minocycline in escalating doses of up to 400 milligrams per day for nine months.

It was a Phase III trial, the widest, final step in a process to see whether a new treatment is safe and effective.

Patients were assessed according to standard measurements for coordination and muscle strength, as well as a "quality of life" questionnaire.

Several Phase II and Phase III trials are either planned or underway to look at minocycline's effect on Huntington's disease, stroke, dementia and multiple sclerosis, their paper said.

http://afp.google.com/article/ALeqM5...JpG9EMtiDWgocA
__________________

.

ALS/MND Registry

.
BobbyB is offline   Reply With QuoteReply With Quote

advertisement
Reply

Thread Tools
Display Modes

Posting Rules
You may not post new threads
You may not post replies
You may not post attachments
You may not edit your posts

BB code is On
Smilies are On
[IMG] code is On
HTML code is Off


Similar Threads
Thread Thread Starter Forum Replies Last Post
He won't let Lou Gehrig's disease win BobbyB ALS News & Research 0 09-25-2007 11:50 AM
ALS Lou Gehrig's Disease BobbyB ALS News & Research 0 08-03-2007 07:03 AM


All times are GMT -5. The time now is 04:33 AM.

Powered by vBulletin • Copyright ©2000 - 2024, Jelsoft Enterprises Ltd.

vBulletin Optimisation provided by vB Optimise v2.7.1 (Lite) - vBulletin Mods & Addons Copyright © 2024 DragonByte Technologies Ltd.
 

NeuroTalk Forums

Helping support those with neurological and related conditions.

 

The material on this site is for informational purposes only,
and is not a substitute for medical advice, diagnosis or treatment
provided by a qualified health care provider.


Always consult your doctor before trying anything you read here.