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Journeys of doubt
Are stem cell treatments in China worth cost, effort?
By CHRISTOPHER BODEEN and ALAN SCHER ZAGIER
Associated Press
Posted: Jan. 13, 2008
They're paralyzed from diving accidents and car crashes, disabled by Parkinson's or blind. With few options available at home in America, they search the Internet for experimental treatments - and often land on Web sites promoting stem cell treatments in China.

Stem Cell Treatments
In China


Photo/AP

Chris Hrabik, 21, has improved use of his hands after undergoing stem cell treatment in China.



Photo/AP

Angela Im receives stem cell treatment in China to repair damage to her brain stem.



Photo/AP

Dawn Barlett sought treatment for daughter Rylea's blindness.

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Buy a link hereThey mortgage their houses and their hometowns hold fund-raisers as they scrape together the tens of thousands of dollars needed for travel and the hope for a miracle cure.

A number of these medical tourists claim some success when they return home.

But documentation is mostly lacking, and Western doctors warn that patients are serving as guinea pigs in a country that isn't doing the rigorous lab and human tests that are needed to prove a treatment is safe and effective.

Noting the lack of evidence, three Western doctors undertook their own limited study. It involved seven patients with spinal cord injuries who chose to get fetal brain tissue injections at one hospital in China. The study reported "no clinically useful improvements" - even though most patients believed they were better. Five developed complications such as meningitis.

Experts in the West have theories about why some people think they've improved when the evidence is thin. Some are often getting intensive physical therapy, along with the mysterious injections; the placebo effect also may be a factor.

John Steeves, a professor at the University of British Columbia who heads an international group that monitors spinal cord treatments, has another theory. Some patients may be influenced by the amount of money they paid and the help they got from those who donated or helped raise money.

"Needless to say, when they come back, what are they going to report to their friends and neighbors? That it didn't work?" said Steeves. "Nobody wants to hear that."

He and other experts have written a booklet advising patients who are considering such treatments.

Western doctors discourage their patients from seeking such treatments. They note that it's impossible to gauge the safety and effectiveness of the treatments, or even know what's in the injections put into brains and spinal cords.

Patients and their families say they accept those risks. They simply don't have time to wait for more conclusive evidence. For many, the trip to China is a journey of hope.

Just how many foreigners are coming to China for treatment isn't known, and China is only one of several countries where such techniques are being offered.

Many Chinese doctors don't wait for results of rigorous testing before treating patients and they offer what they say are stem cell or other cell treatments to those willing to pay.

Lack of publication
What is known about the procedures being performed comes from material on their Web sites or from patients who give detailed accounts of their visits. Little has been published in scientific journals for other doctors to scrutinize.

The use of stem cells for treatments isn't new. For decades, doctors around the world have been using adult stem cells from blood and bone marrow - and more recently from umbilical cord blood - to treat cancers of the blood like leukemia and lymphoma and blood diseases like sickle cell anemia.

Scientists have been exploring whether such adult stem cells and other cells such as those from the retina or fetal brain tissue could be used to replace cells lost because of injury or disease. And they are trying to figure out if there's a way to stimulate the body's own stem cells to make repairs.

But those strategies are still being investigated in the lab in animals; there have been very limited tests in people.

Whether any clinics in China are using the more controversial embryonic stem cells - doctors in some other countries claim to be - isn't clear. These stem cells are taken from days-old embryos. They can develop into all types of cells, but research into their usefulness is in early stages.

Patients seek out these unproven treatments after hearing about them from other patients, patient groups or Web sites for the medical companies.

Chris Hrabik, 21, has been disabled since a 2004 car crash left him with limited use of his hands and legs. His father took out a second mortgage on their Oak Ridge, Mo., home to help pay for $20,000 worth of stem cell injections at a Beike Biotechnology Co. facility in China.

More than a year after returning home, Hrabik says he has nearly complete use of his left hand, with improvement in the right. He can work on his customized 1993 Nissan 240SX, modified with hand controls and racing seats.

He said he was able to move his left fingers within days of that first injection of umbilical cord stem cells into his spinal cord. There's been little progress since he left China, but he called the incremental changes significant.

"I just wanted something back, no matter what it was," said Hrabik, who attributes some of the changes to the physical therapy that he had in China.

Treatment results
Beike founder Sean Hu, who returned from abroad in 1999 with a doctorate in biochemistry, said the company has treated more than 1,000 patients, including 300 foreigners from 40 different countries. The only side effects have been slight fevers and headaches among a small percentage of patients, according to Hu.

He said patients with trauma injuries experience the most dramatic improvements; those with degenerative diseases such as ALS, also known as Lou Gehrig's disease, tend to improve initially but then slide back to their former condition within months.

"Patients shouldn't have their expectations too high," Hu said. "For patients to think they can walk again may be too much at this stage," he said.

Western experts point to the lack of documented evidence that cell treatments have any benefit for spinal cord injuries or degenerative diseases like Parkinson's.

"All of us in the so-called Western world, if there was something valid, we'd be the first to be offering it," said Steeves, the Canadian professor and director of the International Collaboration on Repair Discoveries, known as ICORD.

Three other experts were involved in the study that found no improvement in the seven spinal cord injury patients who went for fetal brain tissue injections in China. The patients were evaluated before and after their surgery.

The doctors stressed their observations were no substitute for a larger, more strict investigation.

Seeking the cure
"People are looking for a cure," said Bruce Dobkin, a neurology professor at the University of California, Los Angeles, School of Medicine, one of the study's authors. "They may come to do something based more on a gut feeling. It's like looking for a religious miracle."

The parents of Rylea Barlett of Webb City, Mo., raised nearly $40,000 from friends and neighbors to spend a month in China at a Beike facility last summer, hoping treatments would cure their daughter's blindness. The child was born with an optic nerve disorder.

Dawn Barlett said her daughter responded to lights shone in her eyes within a week after the first of a series of five stem cell injections and can now make out blurry images on TV.

"She had no vision whatsoever before we left," the mother said. "There was no hope otherwise."

The girl's optometrist, Larry Brothers, said: "It truly is a miracle."

But when pressed for details, he said he detected "subtle differences" in Rylea's optic nerve after her return from China. Asked if he would characterize her progress as incremental, he said that "might be too optimistic."

http://www.jsonline.com/story/index.aspx?id=706077