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Pilot Clinical Trial: Insulin Therapy and Alzheimer's Disease

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Old 09-13-2011, 05:43 AM #1
Lara Lara is offline
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Default Pilot Clinical Trial: Insulin Therapy and Alzheimer's Disease
FYI:

http://archneur.ama-assn.org/cgi/con...eurol.2011.233
Archives of Neurology
Published online September 12, 2011

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

A Pilot Clinical Trial

Suzanne Craft, PhD; Laura D. Baker, PhD; Thomas J. Montine, MD, PhD; Satoshi Minoshima, MD, PhD; G. Stennis Watson, PhD; Amy Claxton, PhD; Matthew Arbuckle, BA; Maureen Callaghan, MD; Elaine Tsai, MD; Stephen R. Plymate, MD; Pattie S. Green, PhD; James Leverenz, MD; Donna Cross, PhD; Brooke Gerton, MD

Arch Neurol. Published online September 12, 2011. doi:10.1001/archneurol.2011.233

Note there were limitations to this pilot study
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Old 09-13-2011, 06:10 AM #2
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I believe Pfizer stopped making intranasal insulin....

I could not find a product available in US currently. There was some problem with patient acceptance and delivery of the insulin was difficult to control and caused irritation etc.

There has been discussion about a Type 3 diabetes existing in the brain. The brain makes insulin, surprisingly and this may fail.
Implicated also in PD.

You may also find this article interesting:
http://www.diabetesincontrol.com/ind...rticle&id=2582
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Old 09-13-2011, 06:48 AM #3
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Wow, it was all over the news here today. Didn't have any idea the nasal spray wasn't made any more.

Thanks for the link. Very interesting indeed.
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Old 09-14-2011, 06:27 AM #4
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http://scienceillustrated.com.au/blo...imers-disease/

New Treatment for Alzheimer's Disease.
Science Illustrated

Quote:
Insulin, the hormone that keeps the level of sugar in the bloodstream within normal range, could be a potential therapy for Alzheimer’s disease.

Endocrinologists from the University of Buffalo (UB) have found that a low dose of insulin could suppress the expression in the blood of four precursor proteins involved in the development of Alzheimer’s, a brain diseases that, according to the Alzheimer’s Association, causes problems with memory, thinking and behaviour. One of the four proteins shown in the study is a precursor to beta amyloid, the main component of plaques—microscopic clumps of protein that have been considered Alzheimer’s disease hallmark. These findings also demonstrate that the four precursor proteins studied are expressed in peripheral mononuclear cells.
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