Caroline2 The article says there are 2 kinds of b6, the active and inactive, one can cause neuropathy if dosed too high. Are you careful to take the active one, or does it matter to you? Also, I posted elsewhere about isonitol(spelling) that you have recommended along with grape seed extract and sphingolin which I am now taking for leg and feet numbness. I have read to be careful of isonitol causing kidney stones. Should I worry?

Sorry, the supplement I was talking about is inosine, not inositol, that may have kidney stone issues.

Hi Jwillis22, welcome to NeuroTalk.

Please be aware that some of these supplements suggested around the place can actually interfere with other psychotrophic medications that people may be prescribed by their doctors.

It's been a long time now since I took it but I think that Inositol actually helps to reduce kidney stones but it's been a while so I might be wrong.

I (and other family members) took Inositol for years. Tubs and tubs of it. Unfortunately it wasn't at all helpful for me. Everyone is different.

I also would look into Sphingolin for whatever reason you are taking that. I personally would never take a supplement like Sphingolin that is made from the myelin sheath of cows, but each to their own.

Hi Lara, thanks for your info. I have just started taking sphingolin for numbness and tingling in feet. I have never had problem with kidney stones but if I do try inosome maybe inositol will prevent them. I am taking .5 alprazolam and paraxetine, so I am careful with interactions. I am just searching all avenues of treatment as of now. Looking into low dose naltrexlone, CBD, and laser therapys.

Jwillis: Come to think of it when I was taking Sphingolin and Inosine for the horrible burn/tingle issues back in time frame of 2012 area, I took both these at the same time for a while...then eventually only Inosine..... Now I take none of them, the bun/tingle is gone, but my whole leg is numb, the nerve damage from the surgery hip replacement.


On Inositol, I take it every night in my sleep combo.

You know Inosine and Inositol are 2 different supplements.

Every one is unique and needs to work with this stuff and their own unique bodies.

Lara, there are many supports that are produced from the organs of animals. I've been taking desiccated thyroid support meds from the bovine. And so many have no clue about these as the synthetic produced meds from labs are what is being pushed and I've been in this loop for a long time.

Yes, I'm very aware that many supplements are made from animals. Most of the supplements are also encased in gelatine. Why they can't all use seaweed I don't know. I've only found one great company here who does some but finding good ones that aren't is difficult.

I see absolutely no need to consume these body parts and suspect they have the potential to be downright dangerous.

I don't see how consuming extremely expensive supplements made from the myelin sheath of cows in the name of Sphingolin is the way to go. In June 2022, after all we've been through I would suggest it's something people at least consider. I would love to hear really good responses from Sphingolin from people who have been convinced to take it but I'm yet to hear that from anyone really except you.

Just my opinion

Jwillis: Ok on this the P5P form of B6 is the activated and more effective..a little more costly but better. I was take P5P for a while early on but the company I was buying from was out of stock and so I bought plain B6 which is inactive. I will buy the P5P when I'm out of my B6..... So as I see it, best to search for P5P wen buying B6. I take 50 mg nightly.

On the Inosine, I've never had issues and I would take it for a few months and then go off for
a while and get back on....I have not been taking it for some time as I don't have the burn/tngle issues anymore

Ok, I just looked further and BlueBonnett has a nice P5P and comes in 50mg capsule in one capsule and even one can alternate and take 50mg one day and take 100mg some other other days. BlueBonnett is a little higher price but they seem to be a high quality product.

Some other P5P products add magnesium and that takes way from the B6 content. Not so with BlueB..