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Thoracic Outlet Syndrome Thoracic Outlet Syndrome/Brachial Plexopathy. In Memory Of DeAnne Marie. |
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11-18-2007, 08:22 PM | #1 | |||
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INVESTIGATOR: Barth Wilsey, M.D.
PROJECT TITLE: The Analgesic Effect of Vaporized Cannabis on Neuropathic Pain PROJECT TYPE: Clinical Study STATUS: APPROVAL PENDING RESULTS: This study has not yet initiated. No preliminary results are available at this time. ABSTRACT: The present study will be designed to evaluate the analgesic effects of vaporized cannabis in patients with neuropathic pain. A within-subject crossover study of the effects of cannabis (3.5% and 1.7%) versus placebo on spontaneous and evoked pain will be performed in subjects with post-herpetic neuralgia, peripheral neuropathy, spinal cord injury pain, post-stroke pain or complex regional pain syndrome. Both pain intensity and pain unpleasantness will be assessed to see if marijuana affects sensory-discriminative pain more or less than the motivational-affective component. If present, areas of mechanical allodynia will be assessed with repeated testing to determine the degree of the allodynia regression (if any) after inhaling cannabis via a vaporizer. Heat evoked pain will be studied using mild to moderately painful heat stimuli delivered to the painful area of the subject's body using an electronically controlled Peltier contact thermode via the Medoc TSA 2001 quantitative sensory tester. Neuropsychological functioning (attention, learning and memory, and psychomotor performance) will be evaluated with the Digit Symbol Modalities Test, the Hopkins Verbal Learning Test and the Grooved Pegboard Test before and after the administration of vaporized cannabis. The degree of antinociception will then be compared with neuropsychological effects of cannabis for a synopsis of the relative effectiveness (efficacy versus side-effects) of the doses employed. The hypothesis will be that vaporized cannabis can induce dose dependent antinociceptive changes in spontaneous and evoked pain in subjects with neuropathic pain. The second hypothesis will be that the higher dose employed induce a greater degree of antinociception that is not independent of differences in mood, cognition and psychomotor performance. Finally, it is hypothesized that an interaction with time will occur such that antinociception will outlast changes in cognitive impairment and psychomotor performance. close found this on this site http://www.cmcr.ucsd.edu/geninfo/research.htm lots of interesting info here on neuro pain love and hugs Victoria
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