[olsen]

"They found that loss of PINK1 resulted in an aberrant calcium overload inside the mitochondria.

This overload stimulated production of dangerous reactive oxygen species that interfered with the ability of the mitochondria to transport sugar needed for energy production. This phenomenon could be reversed by providing substrates for energy production..."

http://todaysseniorsnetwork.com/calc...uced_death.htm

[Jaye]

The colored sentence has me stymied. Thanks, Madelyn.

Originally Posted by olsen

"They found that loss of PINK1 resulted in an aberrant calcium overload inside the mitochondria.

This overload stimulated production of dangerous reactive oxygen species that interfered with the ability of the mitochondria to transport sugar needed for energy production. This phenomenon could be reversed by providing substrates for energy production..."

http://todaysseniorsnetwork.com/calc...uced_death.htm

[olsen]

as per:
This overload stimulated production of dangerous reactive oxygen species that interfered with the ability of the mitochondria to transport sugar needed for energy production. This phenomenon could be reversed by providing substrates for energy production..."

http://todaysseniorsnetwork.com/calc...uced_death.htm

Further in the article is this notation:
"These data strongly suggest that the respiratory complexes in PINK1 deficiency are still intact and that their functional inhibition is in fact secondary to reduced substrate supply," offers Dr. Abramov

thus, the mitochondria are not diseased and the respiratory electron transport chain complexes are also functional--the substrates that constitute the complexes are decreased; ie NADH+CoQ10 for complex 1. Rotenone pesticide is the best known inhibitor of complex 1.

Link for the abstract:
http://www.cell.com/molecular-cell/a...765(09)00129-4

[Jaye]

and a substrate is a substance upon which an enzyme acts, according to the medical dictionary. I'm thinking maybe this discovery is about what makes apoptosis in the substantia nigra happen, which would be very important. I'm guessing, of course. Most of my medical terminology is about stuff you can see. Further dumbing down would be much appreciated, if anyone has the inclination.

[olsen]

Hi Jaye, above relates to mitochondrial dysfunction, thought to be operant in PD--There is not much offerred for mitochhondrial dysfunction--coenzyme Q10 is the primary substance that has been studied in PD. If interested in how to affect the mitochondria, and much of this is not proven because mitochondrial cytopathy is a relatively new target for research, there is a now dated article about Mt cytopathy with suggestions for vitamins and supplements to support this structure: Mitochondrial Cytopathy in Adults: What We Know Thus Far
http://www.ccjm.org/content/68/7/625.full.pdf+html
the United Mitochondrial Disease Fnd. Web Site is a good resource also
http://www.umdf.org/site/c.dnJEKLNqFoG/b.3042181/
Many of the vitamins and supplements taken by members of this forum are also suggested for support of the mitochondria....ie Lipoic acid, L-carnitine, B Vitamins.