[lurkingforacure]

Here's the link: http://stke.sciencemag.org/cgi/conte...ract/2/80/ra36

Now what is interesting, is that one of the things I read about rapamycin is that is appears to mimick pathways that are involved when we eat a calorie restricted diet....and we all know by now that several studies have shown rodent PD reversed when fed only every other day...so this is intriguing to me.

If you google rapamycin, particularly on the news button, you will find lots of articles about rapamycin and life-extension. I have also read that rapamycin suppresses the immune system, which leave one exposed to all the bacteria, etc. out there, but if PDers have an over-active immune system to begin with, all this would do is slow it down, a good thing. Comments?

[reverett123]

The part of the immune system that seems to be the largest problem are the microglia. Rather than suppressing the entire immune system and risking other problems, it might be wiser to just address them.

Among the things that suppress the microglia:
turmeric, green tea, silymarin, and baicalein.

Originally Posted by lurkingforacure

Here's the link: http://stke.sciencemag.org/cgi/conte...ract/2/80/ra36

Now what is interesting, is that one of the things I read about rapamycin is that is appears to mimick pathways that are involved when we eat a calorie restricted diet....and we all know by now that several studies have shown rodent PD reversed when fed only every other day...so this is intriguing to me.

If you google rapamycin, particularly on the news button, you will find lots of articles about rapamycin and life-extension. I have also read that rapamycin suppresses the immune system, which leave one exposed to all the bacteria, etc. out there, but if PDers have an over-active immune system to begin with, all this would do is slow it down, a good thing. Comments?

[Debi Brooks]

It happens that there is an active thread on PDOR about rapamycin and its target, mTOR and its potential therapeutic value. You can check it out here:

http://www.pdonlineresearch.org/resp...r-prevents-lid

Debi Brooks