Parkinson's Disease Tulip


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Old 08-17-2009, 08:33 AM #1
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Default Immune suppresser blocks mutant genes that cause inherited PD

http://www.google.com/hostednews/ukp...jEnTTvyAjWEIkg
Discovery may 'protect brain cells'
(UKPA) – 19 hours ago

A drug given to transplant patients can protect brain cells from rogue genes that cause Parkinson's disease, say scientists.

Rapamycin is an immune suppresser used to prevent transplant organs being rejected by the body's defence system...found that it blocks the damaging effects of two of the mutant genes known to cause inherited forms of Parkinson's...

Because it weakens the immune system, the drug is unlikely to be used to treat patients directly. But investigating how rapamycin prevents the cell death associated with Parkinson's could lead to new treatments.


"...Another exciting outcome of our study is that the positive effects were seen in both flies and human cells. This shows that even simple animal models do work in some cases, and that human cells grown in the lab may be a good method of screening for new anti-Parkinson's drugs in the future..."

Copyright © 2009 The Press Association. All rights reserved.
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lindylanka (08-17-2009)

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Old 08-17-2009, 11:32 AM #2
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I wonder if it really was the genes or was it the suppression of the immune system?

Quote:
Originally Posted by olsen View Post
http://www.google.com/hostednews/ukp...jEnTTvyAjWEIkg
Discovery may 'protect brain cells'
(UKPA) – 19 hours ago

A drug given to transplant patients can protect brain cells from rogue genes that cause Parkinson's disease, say scientists.

Rapamycin is an immune suppresser used to prevent transplant organs being rejected by the body's defence system...found that it blocks the damaging effects of two of the mutant genes known to cause inherited forms of Parkinson's...

Because it weakens the immune system, the drug is unlikely to be used to treat patients directly. But investigating how rapamycin prevents the cell death associated with Parkinson's could lead to new treatments.


"...Another exciting outcome of our study is that the positive effects were seen in both flies and human cells. This shows that even simple animal models do work in some cases, and that human cells grown in the lab may be a good method of screening for new anti-Parkinson's drugs in the future..."

Copyright © 2009 The Press Association. All rights reserved.
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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