YES!!! I just figured out that connection! It took me 2 years to figure it out. The only reason I finally did is because I'm taking my 2nd psychology class in college. I'm 40, diagnosed in 2004. I've done so well. Straight A's, responsible, I can follow through, make appointments on time & can manage my emotions much better. But every 23 days I take extra medication because I'm feeling so out of whack. I have classes to attend, work, homework & was under pressure. I began to think that maybe I was abusing the meds because I was 1 week short every month because I needed the extra help. Finally last week I was so distraught over it that I went into my doctor's office crying & said I was quitting the meds because I was too irresponsible to take it & maybe I was just a drug addict after all! Thank God he knew better. My boyfriend pointed it out to me a long time ago but I just sluffed it off, like what does he know? My sister mentioned it again about 6 months ago, again I ignored it. My psychology teacher pointed it out & with my new knowledge of the brain & neurotransmitters all of the sudden it clicked! I was so relieved to find out what the problem was. My doctor is making accommodations for me in my daily schedule until we can pin point which hormone/neurotransmitter is the culprit, if we can. When I start my period for the next 3 months I will go to get my blood drawn for hormone level checks to see if we can discover the problem. Yes, Adderall XR is ineffective 2 days before and during my period. Absolutely! Thank God I'm not the only one! Thank you so much for posting that. You confirmed it for me.