Hi,

New to this forum but not to NeuroTalk (have been on the Peripheral Neuropathy forum for several months due to non-length dependent small fiber neuropathy. Do recognize some people here from the PN forum.

Have accepted, after searching around for months for other causes, that the Sjogren's Syndrome dx I was given last winter and that was reinforced for me last week, is the underlying cause of the neuropathy. Also have Hashimoto's which is often another component of Sjogren's.

Given that Sjogren's is an AI where the white cells go on an attacking rampage against the self because they think some invader has breached the walls when it hasn't, is it possible that gluten/fructose caused the Sjogren's with the subsequent neuropathy?

Sheltiemom

It is always possible. Gluten intolerance can be acquired, and separate from Celiac it is being found.

We have had several PNers who tested positive for gluten.

I have found fructose to be my major problem. I discovered this 2 yrs ago on vacation.

Fructose is difficult to metabolize anyway and new medical thoughts are to remove it from our diet as much as possible.
There is a liver form and GI form. So far I think mine is GI only.

This is the link to the fructose lecture from UC of SanDiego medical school:
http://neurotalk.psychcentral.com/thread116672.html

Sucrose is 1/2 fructose so it is to be eliminated as much as possible too. But as for whether fructose causes AI disease? That I have not seen yet. Gluten=yes there is a connection.

Vaccines are now often suggested as culprits for triggering AI disease. The LymeRx vaccine caused an autoimmune arthritis in about 40% of those receiving it. Hep B has been implicated in MS and other autoimmune disease. And the new Gardasil and meningitis vaccines have warnings for GBS.

You hypothesize that autoimmune disease happens when the immune system attacks tissue which is not under antigen attack. I disagree. The small intestine's immune system mistakes gluten for fructose-grown microorganisms. The reason? Both have hyphal wall protein1 (HWP1) on their surfaces.

Cells and glutamine are bonded into a matrix by a "cross linked" protein called tissue transglutaminase (tTg). HWP1 is a cross-linking protein. Both gluten and harmful digestive microorganisms use HWP1 to stick to the tTg on the small intestine lining. The immune system detects harmful microorganisms by detecting HWP1. One way it reacts is by releasing the protein zonulin. Zonulin makes the small intestine walls permeable and washes the partially digested small intestine contents into the bloodstream.

So the gut's immune system initiates the zonulin dump in response to both fructose and gluten ingestion. The blood's immune system becomes 1) responsible for handling the results, and 2) overwhelmed.

Gluten is a massive protein. It contains more genetic material than the human genome. Some gluten proteins are "lectins" .......harmful glycoproteins. Some gluten lectins have attachment chemicals identical to the attachment chemicals of the body's own glycoproteins. They plug into bodily tissue in place of natural glycoproteins, and attack the tissue. Unfortunately the tissue most vulnerable to this attack is nerve tissue. The most vulnerable nerves are organ control nerves .....organ transduction nerves.

The attack itself causes disease. If the immune system responds, it causes autoimmune disease. Doctors cannot effectively test for either of these conditions. Only an elimination challenge diet can do this.
..

Are you Krispin Sullivan?
It's just that your posts sound so almost verbatim from his... Just curious.. - j

No. I have read through Sullivan's lectin site several times:

http://www.krispin.com/lectin.html

I'm fighting a complex of my own autoimmune diseases through lectin and sugar abstinence.

Also, because of recent experiences, I'm convinced that lectins and sugar play large rolls in most cancer.
..

Yep. If you can go here...

http://www.bidmc.org/celiaccenter

God Bless!

I am new to this and this is my first time posting in a forum. I have a question as I have been researching all about gluten and if there is a link or correlation between Fucokinase (FUK) gene and gluten. I am wondering if they share the same protein base? I am not in the medical field nor have a background so please keep it simple.