I'm new to this site and just joined today. I was diagnosed with Pernicious Anemia four years ago and have been handling it with sublingual B12. Started out with 1,000mcg every other day for about a year, then 1,000mcg every day and then last year I increased to 2,500mcg a day. I seem to be getting worse not better.

My serum B12 is 1,350 and MMA and homocysteine are in normal ranges now and yet my symptoms are progressively worse. Mostly numbness and tingling in hands and feet and bone weary fatigue; nausea and headaches. I am unable to work because I am just so tired and when I begin to feel better I try to do some light exercises and that just finishes me off.

I started taking B12 shots this week because I figured I just wasn't getting enough somehow.

Anyone know if I can still have good numbers on paper but still need B12?

Thanks for your help!
MusicGirl

I imagine you problem is something else, that hasn't been dx'd yet.

Actually I just found a book entitled Pernicious Anaemia: The Forgotten Disease by Martyn Hooper, who is president and founder of The Pernicious Anaemia Society in the UK. He says that the numbers can be in a good range and yet the person is still suffering the symptoms. That's because the B12 is in the blood but not getting to the cells.

There is active B12 and inactive B12 and when you get your serum B12 tested it will give you the total number, and yet only the active B12 gets into the cells.

Wonderful book that has really shed light on my situation and I am now getting the shots because for whatever reason the sublinguals were not making into my cells, as evidenced by my continued neurological symptoms. I'll keep you posted on what happens, but after four shots, one every other day, my tingling and headache has stopped, and that hadn't happened before.

I'm hopeful this could be it!!

MusicGirl