The immune system operates using leukocytes which sample element sequences of the proteins displayed by antigens. These leukocytes communicate these sequences to the thymus and spleen. The thymus and spleen create and mature new leukocytes programmed specifically to recognize the sampled antigens. These leukocytes kill and devour the antigens and the tissue which has been compromised by the antigens ....extremely exacting.

The entire process is controlled by nerves. Nerves are controlled by endorphins, the body's own pain killing narcotics. Some of the foods we eat contain endorphin mimetic proteins .....opioid exorphins. These proteins plug into nerves at inappropriate times. They cause nerves and organs to stop performing, or to perform inappropriately. When this happens in thymus and spleen nerves, it degrades immune function. The immune system is forced to dumb itself down. In dumbed-down mode the immune system ceases to discriminate between antigens, and ceases to discriminate between antigens and human tissue. The result is autoimmune disease.

Naltrexone is a drug which blocks nerve endorphin receptors. It was developed to reverse the ill effects of heroin addicts who overdose. Reportedly, after a few hours, naltrexone makes these people feel HORRIBLE. That's because it blocks both heroin and endorphin. And people require endorphin. Naltrexone's inventor got the idea of using Naltrexone on people with autoimmune diseases. It worked, but made them feel awful. Subsequently other doctors experimented with low doses of Naltrexone, taken nightly. Reportedly, it works like a charm.

Another possible drug to look into is clofazimine. Leukocytes communicate the above immune processes with thymus and spleen nerves using kv1.3 potassium ion channels. When ingested opioids make control nerves sluggish, they degrade the function of these potassium channels. Clofazimine restores potassium channel function. Clofazimine has a side effect which many people don't like. It discolors the skin .....to different degrees, and in different tones, depending on the patient.

‘Course instead of attempting to cure the problems caused by ingested exorphins you could just stop ingesting them.
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I have Trigeminal Neuralgia altho it has never been linked to my lupus. Unfortunately I can't say lupus caused it or dental trauma or just bad luck but it's here and I live with it daily. Good luck in your adventure.

Hello, and I believe as you do. there is a connection in all the auto immune diseases. I have multipal. Had a bad bad virus at 29 years old and while on the er table i felt a tingle all over and on my hair as well. In six weeks my waste lenght hair dropped out. since then it has been one after the other. Artritis, bone degeneration, joint degenerations, barretts esphogus, and of course the origional alopecia universalis. I have never been well during these years, and wind up with infections that do not cure easily. I have been to Mayo clinic, and disease specialists, nobody is making that connection. I am positive they are all related. I am now 60 and really sick with barretts esphophagus, can't control the acid in my stomach and the cells are turning up abnormal. Cervial troubles ended with bad cells too in which my hysterectomy took place. All in all I hope to find people here to with multipal problems in their bodies. I wish you all the best and I hope a thread can be started for multipal auto immune conditions. I also pray for this site. do write any time. I am changing services, but I will be back around. ginnie

I am so glad I found this talk. I also have neuropathy and progressive muscle disease along with UCDT that they first told me I had lupus then scleroderma, I have microscopic colitis for which I have been in a flare for two months, I am hypothryoid, Reflex, Raynauds, photosenstive just to name a few of my autoimmune problems. I am on my way to a teaching hospital to get a second opioion. So when I seen this forum I was like yes, nobody esle gets it. I do have to ask what you girls take for the neuropathy? I am on a pill for anti siezures called carbamazepine anyone else on this? Also do not want to take predisone. I have issues with that.
Right now, I am having new symtpoms of burning scalp it is really bothersome it feels like when you were a kid and your ponytail was pulled to tight, sort of. I am thinking it is a neuropathy thing. But cannot find a lot of info on it.
Thanks again for letting me add my two cents.
Susie

Maryec, I have the same dx as you. I have connective tissue disease with features of lupus and scleroderma. What meds are you on? Do they consider your myopathy progressive? They do mine and it seems to be progressing more than I thought. Any input would be great.
susie

Hi Kami, I hate to say that I was happy to see someone else with the immune type of colitis, I have the same. When I talk about it nobody knows what I am talking about. I also have neuropathy, progressive muscle disease, they teseted me for MS I have UCTD with features of lupus and scleroderma.
May I ask what you are on for the collagenous colitis? I have had a two month flare they are trying everything, wants me to go on steriods, but I do not want to, hear too many bad things about it, plus I do not need to gain anymore weight. You would think with the colitis I would lose, but now me. I also have hypothryoidism immune style. I was not gettingenough synthroid so they just upped it, hope that helps with the weight too.
Hope you are feeling well,
susie

Hello, Lily. I also have peripheral neuropathy related to Sjogren's - about 4 years. I have tingling in arms and legs as well as pains that some and go all over my body. I'm very interested in your supplementation regimen. Just recently I've discovered that B-12 seems to stop some of my pain and weird numbness sensations. But it think I'm needing a crazy amount like 2000 mcg at least daily. I've tried the benfotiamine a couple of years ago and still have some, so I'm thinking of trying that again. Will you please give specifics on your dosages and some of the your logic and experience with these supplements. I would be so so grateful for your sharing!

Thanks so much, Michelle

I was diagnosed with primary Sjogren's syndrome in 1998. Then short time later I noticed numbness in my toes and then feet. Have a sensory neuropathy, which EMG could not diagnose, because its short fiber neuro. It affects my balance, which is difficult to tolerate. Try and do exercises for that, does anyone know any good ones for balance? I also have autoimmune thyroiditis. I use gabapentin, and locally lidocaine ointment on feet.