Hi, I have a sister 45 yrs old. She was diagnosed with MS last year. Her symptoms were in her one eye. 20 yrs ago had problems with it and given massive steriod treatment for about a year. Started up again last year and diagnosis was found. My question is has anyone with MS tried the active forms of B12. MethylB12 and AdenosylB12 as a form of treatment for their MS? I have done quite a bit of reading on the subject and have gotten the active forms. Ive also added megafolonic and B-Complex to her vitamin intake. She has always eaten a very good diet. Our family has a history of B12 problems. Autoimmune probs on fathers side. (Rhu Arth, MS, Pern Anemia) Her B12s are in the mid 400s. I know this cant hurt her to take and am hoping it will help with MS too. Anyone???? PS She takes no MS meds so far. When her eye calms down she is fine.

I think what you are doing will help:

from http://www.ncbi.nlm.nih.gov/pubmed/1...ubmed_RVDocSum

If you go to this article, a bibliography will appear with similar ones on the right side of the page.

Hi cindyd,
B12 is a tricky subject. For instance, 400 is a "good" level with you consider that many labs use 180 or 200 as the low for "normal". The thing is, in some other countries the low for normal is 500 because that is the level at which cognitive problems can begin to be found.

The doctor who prescribed a shot a day for me for a year tried to keep her patients' levels at 1000-1200 or above.

Diet is a bit deceptive because if there are absorption problems the very best diet is not getting translated into usable B12 in the body.

While it's a bit fiddly, I do think keeping daily notes while using B12 is of vast benefit because that way you can look back and see what actually has changed.

Sublingual methylcobalamin lozenges need to be taken consistently in order to build up to the amount of B12 that is given in a shot, so the results aren't quite as quick as getting shots, but after the initial period where the amount is building up, the lozenges are GREAT!