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05-22-2009, 06:54 PM | #1 | |||
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Legendary
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Hi all,
just following up on research regarding eslicarbazepine - a drug (AED) i ran across years ago, and found it is coming to fruition.... about nowish! Sepracor Announces Submission of Stedesa New Drug Application to FDA for Adjunctive Treatment of Epilepsy it has already been approved in Europe (not sure if on market yet though.) for more articles on eslicarbazepine (Stedesa): More articles on eslicarbazepine (Stedesa) at drugs.com This drug is supposed to be really good with refractory partial seizures, and supposed to help with depression too (!), but it is unclear if the implication is helping with being depressed from having uncontrollable seizures (that's depressing! ), OR - more pertinently to us - if it actually has antidepressant properties. What is unclear is whether non-epileptic depressed individuals were included in the trials. It is however implied that it shows potential both for epilepsy and affective disorders. Another thing. It is related to carbamazepine (Tegretol) and oxcarbazepine (Trileptal) so one might expect cross-sensitivity in individuals who have had issues with these two drugs. However, the structural difference of this drug does imply an improved safety profile, as well as different metabolic pathways than either carbamazepine or oxcarbazepine. Here's the abstract to a tech article on the drug, although from it i cannot deduce what the potential for any cross-sensitivity might be: Eslicarbazepine Acetate (BIA 2-093) Neurotherapeutics, Volume 4, Issue 1, Pages 88-96 L.ALMEIDA Quote:
Or if anyone else finds anything more specific, esp. regarding the cross-sensitivity, please add to the thread! ~ waves ~ 1 large coffee + 600mg ibuprofen = doing mostly better Last edited by waves; 05-23-2009 at 06:12 AM. Reason: removed repetious section |
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05-22-2009, 09:44 PM | #2 | |||
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Legendary
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i cross posted this to the Medications Forum (seemed appropriate). i am leaving the full text post in this thread all the same, since it's already here, however i think that the Meds Forum thread would be the ideal place to reply if you have added information regarding the med in general.
here is the thread in the meds forum: New AED/stabilizer up for FDA approval - eslicarbazepine (Stedesa) i think perhaps this thread could still be useful for us should we want to post comments regarding its impact or usefulness specifically for bipolar, at least, that is what makes sense to me. i hope i have not confused anyone. ~ waves ~ |
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05-23-2009, 06:03 AM | #4 | |||
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Legendary
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Lol, Mari, you are a trip. well that made me smile.
just to be clear, i wasn't trying to fend off people from posting here... maybe it came off that way a bit. lol, now i wonder if my post in the E forum had the same effect. i think here is good to post information or experiences with the med specifically for bipolar. just if someone has more specs or general info on the med that would apply to all pathologies, it would seem to make sense to put that in the med forum thread (linked above). Last edited by waves; 05-23-2009 at 06:05 AM. Reason: thanks for replying |
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05-23-2009, 12:37 PM | #5 | |||
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Wisest Elder Ever
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I am wondering about this new medication, I was on trileptal and it stopped working for me aand I became hyponatremic, low sodium, anemic and increase in WBC from it and that is when we switched to lamictal.
So I will watch for further developements.... thanks beth
__________________
. Hattie the black and white one wrestling with hazel, calico. lost hattie to cancer..... Happiness is a decision.... 150mg of lamictal 2x a day haldol 5mg 2x a day 1mg of cogentin 2x a day klonipin , 1mg at night I will not give up in this weight loss journey, nor this need to be AF. 3-19-13=156, 6-7-13=139, 8-19-13=149, 11-12-13=140, 6-28-14=157, 7-24-14=149, 9-24-14=144, 1-12-15=164, 2-28-15=149, 4-21-15=143, 6-26-15=138.5, 7-22-15=146, 8-24-15=151, 9-15-15=145, 11-1-15=137, 11-29-15=143, 1-4-16=152, 1-26-16=144, 2-24-16=150, 8-15-16=163, 1-4-17=169, 9-20-17=174, 11-17-17=185.6, 3-22-18=167.9, 8-31-18= 176.3, 3-6-19=190.8 5-30-20=176, 1-4-21=202, 10-4-21= 200.8,12-10-21=186, 3-26-22=180.3, 7-30-22=188, 10-15-22=180.9, |
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09-14-2012, 01:12 AM | #6 | ||
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New Member
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I am a survivor of head injury, meningitis, coma and cavernous hemangioma: right parietal lobe. All "oh how fortunate you really are" aside, I do suffer from partial seizures. I have been on a variety of anti seizure meds. Most gave me no problems except ocassional extreme tired or perhaps times when we shouldn't operate machinery... things like that. Now I am on that study drug, eslicarbazepine. What effects that were abnormal for me were numb lips, no big difference in partial seizure occurance, though it did decline and two very specific incidences. They occured in less than two months apart from eachother. First, I had a sensation that was quite like the delerious physical sensation I felt first coming out of and recovering from coma. Second, I had not had a tonic clonic since just prior to 2006. I had then had a startling cluster of years there with sudden onset tonic clonic, indicitive of mri need which then discovered the cavernous hemangioma at the surface. Operated and removed, I had not had one since this month. This is alarming to me. Maybe I am a bad candidate for the medicine investigation. Yet, at the same time, I believe that someone with a great deal of brain damage, such as myself, also might be an excellent candidate for the investigation, that we might learn just how intricate the new med for the fda will behave. Chiming in with Android, BarbarG.
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09-14-2012, 12:02 PM | #7 | ||
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Legendary
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Welcome Barbara
And thank you for the information on how it has effected you. My son has had all kinds of seizures. He has what is the VNS, right now and is on 3 medications, Lamictal, Trileptal and dilantin. He was on Tegretol before the trileptal it was his first medication. And he has been on most of the other medication, except phenobarb. He is finally controlled, but we are right now reducing his trileptal, its the one drug that is causing the most in cognitive effects I believe. So it would be interesting to me to see how this new one does in the trials. And after if it is approved in the states. I have many friends who's children and many adult friends who need new medications. Thanks Waves for posting this. Donna |
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