[ordinarygirl]

Has anyone tried or is anyone currently on a combination of Lamictal and Lithium for mood stabilization?

I've been on Lamictal and an antidepressant together for quite some time and because I am incredibly sensitive to medications and their side effects have been maintained at a sub-therapeutic level. The past few months, though, I've been sort of rapid-cycling (I'm Bipolar II, so basically get obsessive-compulsive and very anxious instead of high manic) and feel TERRIBLE!

My pdoc wants to try a "Lathictal" combo before adding anything else to the mix for anxiety or OCD symptoms. I start the Lithium tomorrow and am looking for some thoughts as to what to expect. (never been on it before)

[Mari]

Hi,
I was on lithium years ago.

Are you taking an anti-depressant? That can make rapid cycling worse.

I remember that Lithium takes about 4 weeks to start working.

Drink fluids.


Mari

[bizi]

WElcome ordinary girl.
I agree with mari, the anti depressant could be causing you the problems.
what anti depressant do you take?
I take lamictal which also acts like an antidepressant.
bizi

[ordinarygirl]

Originally Posted by bizi

WElcome ordinary girl.
I agree with mari, the anti depressant could be causing you the problems.
what anti depressant do you take?
I take lamictal which also acts like an antidepressant.
bizi

Yeah, I've been down the antidepressant causing trouble road over the years. Obviously SSRIs are a baaaad idea. Currently I take Wellbutrin XL. I've taken the combination of Wellbutrin and Lamictal for years and while I haven't done fabulously, it's worked much better than anything else I have tried in the past, oh, 15 years or so.

I may not have been clear, it's not the rapid cycling I'm trying to figure out, just the possible effects of the Lamictal/Lithium combo.

There have been a lot of stressors in the past few months which have contributed to finally knocking off-kilter the precarious balance. Thus, adding another mood stabilizer to the mix. Ah, more meds...

[bizi]

I think I remember somewhere reading that lamictal could be used with lithium...sorry don't have any links for you.
there is a sister fourm here called psychcentral they have an active bipolar forum there as well, you may want to post there too.
bizi
http://forums.psychcentral.com/forumdisplay.php?f=11

[Mari]

Hi,

Lithium is old and well studied. You should be fine.

Here is a study from 1999 showing that Lamictal does not interfere with Lithium.
http://www.pubmedcentral.nih.gov/art...?artid=2014987

Nevertheless, the interaction at higher lithium dosages and during long-term coadministration remains to be studied.

We did not study the potential for lithium to alter the systemic concentrations of lamotrigine. Lamotrigine is inactivated predominantly by glucuronic acid conjugation, which is not involved in lithium elimination. We would not expect lithium to affect the pharmacokinetics of lamotrigine.

In conclusion, lamotrigine does not cause significant change in the pharmacokinetics of lithium.

This page says that there no interaction with lithium and lamictal has been reported.
http://www.psycom.net/depression.cen...motrigine.html

Mari

[AmICrazy]

I had been on 400 mg of Lamictal for about 4 years and then stopped taking them for a year when I got separated and divorced. My girlfriend who is now my wife urged me to get back on meds because I got really really bad. I'm now on 400 mg of Lamictal again plus 900 mg of Lithium. Everything seemed to be fine for the past 9 months but the weather has recently changed as we go into Fall and I'm starting to feel like when I wasn't on meds. I'm calling my shrink today to see what else he can do.

[Mari]

Originally Posted by AmICrazy

Everything seemed to be fine for the past 9 months but the weather has recently changed as we go into Fall and I'm starting to feel like when I wasn't on meds. I'm calling my shrink today to see what else he can do.

Hi,

Some people get depressed as the season changes from summer to winter.
Can you get outside and get sunshine?

M

[Dmom3005]

If you can't do that the other thing I know of is the special light bulbs
or lights.

Donna

[bizi]

I am glad that you are seeking help. this is a good sign...
sorry you are feeling unstable.
bizi
welcome to the forums