One of the top non-digestive symptoms those with IBS struggle with is fatigue. Fatigue can be described as tiredness, lack of energy, or a state of exhaustion. While fatigue is not a direct lower gastrointestinal (GI) symptom, it is commonly found as a symptom according to quality of life surveys done by large numbers of IBS patients. The studies show an increase in fatigue with an increase in symptoms, fatigue paired with depression and anxiety, an increase in fatigue with an increase in stress, and worsened severity of fatigue during menstruation. So why is this link seen, and what’s the cause?