Chronic Pain Whatever the cause, support for managing long term or intractable pain.


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Old 02-03-2010, 09:41 AM #31
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Default taking neurotin

Ijust began taking gabapenti for burning feet.I'm glad to see I'm not crazy about the sideeffects.Sometimes I think I'm a big baby but this burning is something has anyone ever had it stop....Can I look forward to any improvment
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Old 02-04-2010, 03:41 AM #32
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Frown lyrica unknown dangers

Quote:
Originally Posted by gambles View Post
Anyone out there use Lyrica or know of anyone who does?? So far I have met two people who have had fantastic success with it to the point of getting off narcotics!

It is off label prescribing, but my fear is that is is closely related to the anti-convulsant drugs which I didn't do very well on. I tried both Topomax and Neurontiin with devastating results. I know other people with spinal injuries have had luck with both of those meds also.

Anyone have any stories or thoughts about Lyrica??

Thanks for any info,
Suzanne
Suzanne,
I have done extensive research on Lyrica. My fiance was taking it for nerve pain due to a spinal cord injury. I also was prescribed it for fibromyalgia. I quit taking it rather quickly as I became depressed. With my fiance, he began having blurred vision; confusion; amnesia; ataxia just to list a few. He had to take massive amounts for it to touch his nerve pain, just as it had been with the neurontin. I have been in the pharmacy business for 13 years. Number one, I am very leary of trusting any new drugs to start with, but more specifically drugs made by Pfizer or any of their subsidiaries. They are known for withholding information from the public on the dangers of medications that they put on the market. Vioxx and bextra to name two. What I have found is alarming. First, this drug is extremely hard on the kidneys. If you have even mild kidney problems it could be deadly. Two, and more worrisome A shocking new study shows that they block the formation of new brain synapses, drastically reducing the potential for rejuvenating brain plasticity – meaning that these drugs will cause brain decline faster than any substance known to mankind.
Quote:
The problem of these drugs is compounded by their flagrant illegal marketing. Neurontin was approved by the FDA for epilepsy back in 1994. The drug underwent massive illegal off-label promotion that cost Warner-Lambert 430 million dollars (the very first big fine for off-label promotion). The drug is now owned by Pfizer. Pfizer also owns Lyrica, a super-potent version of Neurontin. It has been approved by the FDA for various types of pain and fibromyalgia. Lyrica is one of four drugs which a subsidiary of Pfizer illegally marketed, resulting in a $2.3 billion settlement against Pfizer.
Even though the marketing of these drugs has been heavily fined, they continue to rack up billions in sales from the off-label uses. Doctors use them for all manner of nerve issues because they are good at suppressing symptoms. However, such uses can no longer be justified because the actual mechanism of the drugs is finally understood and they are creating a significant long-term reduction in nerve health. The researchers in the above study try to downplay the serious nature of the drugs by saying “adult neurons don’t form many new synapses.” That is simply not true. The new science is showing that brain health during aging relies on the formation of new synapses. Even these researchers managed to question the common use of these medications in pregnant women. How is a fetus supposed to make new nerve cells when the mother is taking a drug that blocks them?
These are the kind of situations the FDA should be all over. As usual, the FDA is sitting around pondering a suicide warning for Lyrica while its off-label uses include bi-polar disorder and migraine headaches. The FDA is likely to twiddle its thumbs for the next decade on the brain damage issue.
The above quote is copied from http://www.wellnessresources.com/fre...rain_synapses/

Yes, I personally found that the drug helped with the pain, but the risks far out way the benefits for myself. I hope what information I have given you has helped. You are right to be hesitant to try this new drug. It will be years before it is truly known to what degree this drug is damaging the brain, and who knows what else.

Last edited by Chemar; 02-04-2010 at 08:52 AM. Reason: website quoted has copyright
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Old 02-04-2010, 09:38 AM #33
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I for one, will be watching closely to see if the studies on Lyrica continue concerning its damaging potential.

And also, Vioxx was not a Pfizer drug. It was marketed in US by Merck. Bextra was a Pfizer me-too drug, and Pfizer also markets Celebrex (after merging with Searle). All 3 are Cox-2 specific inhibitors. Vioxx was the most potent of the 3 and Celebrex the weakest.
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Old 02-04-2010, 03:13 PM #34
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Quote:
Originally Posted by Idealist View Post
I took neurontin for about a year and a half, and then switched to lyrica. There were some differences, but most were bad. End the end I elected to quit taking both of them. For me, the side-effects were far more noticeable than the benefits were. Good luck!

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if you dont mind I was wondering what side effects you had from neurotin.I take gabapentin and I don't like it either...
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Old 02-14-2010, 03:38 AM #35
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Default neurontin/gabapentin

I have had diabetic neuropathy for a few years, however according to my neurologist it's reversing which nearly knocked him over because he's never seen it happen in any of his patients before. This is hard for me to talk about because of what the Neurontin did to me, I mean the Lyrica was psychologically damaging just as Cymbalta was I became very suicidal on Lyrica and Cymbalta but the Neurontin nearly killed me and I'm only learning now that I wasn't just in ketoacidosis, I was in either metabolic or lactic acidosis which according to some recent research I've done is exactly what happened to me a little over 2 years ago, I'd been on the starting small dose of neurontin for a few weeks and it made me so tired and sick all the time, I was forgetting things and could barely get out of bed to see the doctor who prescribed me the medication, but I did go I told them what was going on and they lowered the daily dose but upped the nightly dose but when I tried to explain that I just didn't feel right that something was wrong they ignored me completely, with in 24 to 48 hours I was laying on my bedroom floor literally dying, the medication had severely dehydrated me and yes I was drinking massive amounts of water, I woke up my heart was pounding I was so sick to my stomach and I had a horrible headache, when I finally threw up I got much worse I really thought I was going to have a heart attack or a stroke. I was lucky to live through it, especially with out having a massive heart attack, my sodium and potassium levels had dropped so low the doctors were very scared and told me if I hadn't have gotten to the hospital when I had I would have been dead. I wasn't allowed to eat for several days because there was next to no water in my body at all, I could hardly breathe I felt like I could feel my body shutting down and dying. The next day it hurt just to breathe, my whole body hurt so bad from going through what it had because of that medication that even my family who saw what I went through and how hard I had to fight just to survive were surprised that I lived. I had to take huge doses of potassium while I was in the icu and was talked with about changing my doctors and never taking the medication again, which at the time I was on tramadol as well which that caused issues with my heart murmur so they told me to stop that as well. But the main culprit was the neurontin. For a little over 3 weeks I had badly blurred vision because of what had happened, it did go away eventually and my eye sight is fine now but it was still a very scary ordeal for me. I think these days especially because of the economy that doctors look for the bigger pay out for prescribing a medication then what's best and safest for their patient. I've been doing a lot of research lately because of something a specialist said to me this past week and I'm not liking what I'm seeing, in some cases yes it can help some people, however neurontin and several other medications including anticonvulsants that doctors are using to help treat nerve pain as a whole, not just neuropathy, are in consideration for being recalled because of how dangerous these medications are especially when they don't know what the effects of long term use are in these patients. I may not be a doctor or have a medical degree, but that was on a website a real doctor had put up to inform people. I was even told by the specialist I had seen this past week that he hasn't even researched a medication he was trying to give me and I really felt like he was trying to push it on me by saying if it were them they'd be begging for it. The same specialist also said that nerve conduction study's and emg's are bogus, which obviously I don't believe him other wise there would have been no basis for the carpal tunnel release operations I've had. At this point until doctors can not only be honest with me but do the research and understand fully what it is their giving me then why should I trust them? I trust certain ones but lately it seems like I'm being yanked around when they can't even do the research to back themselves up, if your a doctor it's your responsibility to know what your giving to a patient and essentially our lives are in your hands, if you don't feel right and your on neurontin I strongly urge you to seek medical attention and request that medical professionals or a hospital do blood work immediately to check your sodium, electrolytes, potassium etc., like I said I'm not a doctor but speaking from what I went through it's not something to be ignored even if it's just your gut feeling that something isn't right if you at least get the tests done at least you'll know and make sure your doctor checks them frequently.
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Old 02-14-2010, 01:03 PM #36
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I couldn't take any of them! Pregabalin, gaba, whatever. Cymbalta made me deathly ill! My pharmacist says these are drugs that either your body likes them or doesn't, no real in-between....... so I agree, if it doesn't make you better, quit it!

Now, part of my issue with medications is I'm allergic to the synthetic fillers. If I try a new med, it has to be a brand name that doesn't have some cheap filler in it.
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Old 02-15-2010, 01:22 AM #37
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Default neurontin

I did stop the medication but these days what I deal with is hard to explain, according to the neurologist my nerves are waking up and not only am I hypersensitive to everything where the neuropathy pain is concerned but I've become highly sensitive to medications as well and even requested to see an allergist to make sure. I think everyone's body's and problems with nerve pain are different as well as their response to treatment but I think if doctors listened more to their patients and researched the medications and their effectiveness rather than drug companies that a lot of people wouldn't be having these issues, to be honest according to what I've seen there weren't that many people in the trials that actually experienced complete relief and if long term use of these medications hasn't been studied properly then the FDA should have never approved them, as many recalls as there have been on a lot of these kinds of medications because of all new dangers it makes me understand why so many people these days don't even want to see a doctor let alone go to an er for a true emergency. For now I have bigger concerns, the hospital my mom was taken too Tuesday released her with out telling us her head cat scan showed she has had a stroke, with everything going on with her and the reason she was taken by ambulance being that her doctor thought she may have had a stroke first off why didn't the hospital tell us and secondly why didn't they keep her over night? We only just found out through a letter from her doctors office, no one called and the er didn't inform us what so ever and it's quite possible it could have been caused by long term use of an anticonvulsant that I recently found out has caused the same problems in other patients, even patients on it just for migraine prevention. I guess it's time to make a trip to the medical board my mother wasn't treated properly in that hospital in my opinion, they told us her cat scan was perfectly normal and maybe I should go see a lawyer.
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Old 02-17-2010, 11:03 AM #38
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I am one for whom Lyrica seems to be working quite well. Some of the side effects are really annoying- weight gain, yes. appetite, yes. Aphasia and word replacement, yes. But considering that only a few weeks after starting it I was doing things like rearranging bookshelves and making fudge, we're all willing to deal with it. I also get roaming patches of numbness.

I might ask about trying Neurontin instead at my next appointment, but I'm afraid to mess with something that is really working.
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Old 02-17-2010, 03:53 PM #39
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Default I"m a lyrica user

Quote:
Originally Posted by gambles View Post
Anyone out there use Lyrica or know of anyone who does?? So far I have met two people who have had fantastic success with it to the point of getting off narcotics!

It is off label prescribing, but my fear is that is is closely related to the anti-convulsant drugs which I didn't do very well on. I tried both Topomax and Neurontiin with devastating results. I know other people with spinal injuries have had luck with both of those meds also.

Anyone have any stories or thoughts about Lyrica??

Thanks for any info,
Suzanne
I've been on Lyrica for about 6 months now. It works on my nerve pain but I still have some breck threw pain. I was taking 50mg and had to get it reduces to 25mg because one of the side effects is depression. Well I got depressed and now I'm on an anit-depressant meds now. I dont have any other side effects. Thank god
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Old 02-21-2010, 07:33 PM #40
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Default I take Lyrica

I've been taking Lyrica for about a year now, 300 mg daily. I also took Neurontin, but I was up to 2400 mg before it even touched my nerve pain. The Lyrica works better for all over pain, including Fibro. I don't know what I would do if I didn't take Lyrica or Neurontin for the nerve pain??

So, what do you take for the nerve pain if not Lyrica or Neurontin? I wouldn't be albe to get out of bed, and I am on a fentenyl patch as well...
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