I guess it depends on what you call "mega".

B5 RDA is 5mg a day.

You take 500... so you take 100 times the RDA.

The B12 mega is 90% non-absorbed orally, so even though it appears to be mega, it is not.

I think your dosing is quite high, compared to what most people consume in this country daily.

Good point. Looking out on the web, some of the studies that have been done, and dosages being taken, are 10 - 20 times or more what I'm taking.

I've been experimenting with lowering the amount. The well-known 1997 study by Dr. Leung used 5-10 grams/day to treat acne. This has been modified downward by Dr. Jeffrey Dach by combing with L-Carnitine, but the amounts are still 750 mg B5 (pantethine) + 250 mg L-Carnitine, 3 times/day. I can control my acne pretty well with what I'm taking (which is even far less than Dach's lower dosage); any less and I break out. Others on the web are reporting results with dosages equal to mine.

My plan is that once my adrenals are back in range, I'll be reducing dosages (and/or frequencies) of everything.

Doc

My lab results are in. 3 out of the 4 adrenal hormones I've been tracking/treating are now well within normal range, and I am feeling very good in some respects -- particularly in spirit. However the 4th hormone level is still significantly below minimum, even for my age, etc. which has me concerned. I'm thinking of considering another cause/reason for this, so I'll have to spend some time "digging in" (so to speak).

I'm still somewhat in awe of how much better I'm feeling/coping with the pain, yet still wondering how much better still things could/might be if I could get that 4th level within normal range.

I have to say that this therapy has proven (IMO) to be a qualified success -- VERY worthwhile -- and I encourage any/every chronic/intractable pain patient to get their adrenal hormone levels tested as per Dr. Tennant's articles/recommendations (See Post #1 of this thread or Post #12 in the Useful Sites & Resources "Sticky" thread).

This therapy has worked better for me than any other Pain Mangement Therapy tried. Q.E.D.

Best wishes, and less pain!

Doc