Hi, Dr. Smith:

No, Dr. Smith. I have absolutely no doubt that it was naltrexone, not naloxone, that was used in some fentanyl patches during the clinical trial in which I participated.

Take a look at this (I hope the link works); I was part of a similar clinical trial done a few years earlier:

http://www.clinicaltrialsfeeds.org/c...ow/NCT00650182

If the link does not work, you will have to type the link in the box starting with http://www. (I do not know the technical name for that box).

Read what you see on this page. Then click on:

Click here to view the journal abstract from the study manuscript.

You will be able to see and read the Protocol Final Report.

Quote: "As I understand it, they should have brought your opioid levels down considerably before trying this, and even then there is a specific protocol that must be adhered to and carefully monitored. Somebody (and possibly more than one) messed up." This is also what I think. At the time of the clinical trial I participated in a few years ago, I was on the 75 mcg dosage of Duragesic.

Three things:

1. The first link works fine; the second, detailing the final report, does not.

2. My recollection is apparently deficient; this could be from initial misunderstanding or memory problems. My apologies - I need to review this stuff.

3. I now think your reaction may have been just that - some kind of bad reaction - and perhaps not a withdrawal, but I sure don't know fer sure.

Doc

Hi, Dr. Smith:

Once you click on the first link, go all the way down the page and you will find something saying "Click here to view the journal abstract from the study manuscript." You can click on the second link from this page, not from the Neuro Talk page (which was only for informative purposes). You have to have Acrobat Reader to open this pdf document. I tried this morning from my computer and it worked.

Quote: "I now think your reaction may have been just that - some kind of bad reaction - and perhaps not a withdrawal, but I sure don't know for sure." I am not sure if my problems with the fentanyl patches with the naltrexone were caused by a bad reaction or withdrawal.

Just thought I'd follow up about the low dose naltrexone.

It is off label use, my Dr. did disclose that to me. I have severe neuropathic burning pain all over my body and severe neuropathic itching too. I did one month of LDN and it was not a success for me. I had read alot about how it was this wonder drug for pain, but unfortunately it was not for me.

BTW, I use Vicodin for foot pain, and my vicodin DID NOT work when I was on the LDN.