Warning issued on dangers of methadone

Wittesea · 11-27-2006, 01:37 PM

This was posted in the Health News Headlines forum here at NeuroTalk.

http://news.yahoo.com/s/ap/20061127/...hadone_warning

Quote:

WASHINGTON - People starting treatment with methadone have died and suffered life-threatening side effects, health officials said Monday in warning of the dangers of overdosing on the painkiller.

Overdoses of the increasingly popular narcotic can cause slow or shallow breathing and dangerous changes in heart beat that patients might not feel, the Food and Drug Administration said.

Those side effects, including reports of deaths, have been seen in patients starting methadone treatment for severe pain or who switched to the drug after using other strong narcotic pain relievers, the FDA said in a public health advisory.

The FDA warned that methadone only provides pain relief for four to eight hours, but can linger in the body for eight to 59 hours. That can lead patients to take more of the drug before it has been eliminated by the body, causing the drug to build up in the body to toxic levels, the FDA said.

Doctors should prescribe methadone carefully and closely monitor patients on the drug, the FDA said. Doctors also should thoroughly instruct patients how to take the painkiller, warning them not to take more than prescribed without first checking with the doctor, the agency added.

Methadone use is rising, especially for the treatment of pain, with more than 2 million prescription dispensed in 2003, according to the FDA. Increased reports of deaths and serious injuries have accompanied that greater use.

In 2003, methadone was listed as a cause of 2,452 unintentional poisoning deaths in the U.S., up from 623 in 1999, according to the National Center for Health Statistics.

The FDA also said it updated the label for the methadone product Dolophine to include new dosing and other information.
A spokesman for Boehringer Ingelheim Pharmaceuticals Inc., whose Roxane Laboratories subsidiary makes Dolophine, did not immediately return a call seeking comment.

Methadone is similar to morphine and is most widely used to treat severe pain. The drug also is used in the treatment of heroin addiction.

On a personal note-

It's about time someone started noticing the half-life concerns with Methdaone. For years and years I have seen patients on chronic pain forums warn each other and discuss the half-life... I myself used to do the half-life math for people so that they understood how much Methadone was in their system by the 5th day.

It's a great pain killer that works well for so many, so I'm glad that this major safety issue is finally getting enough attention so that doctors can be more aware and more cautious when they prescribe it to their patients - and so that patients can be more aware of the half-life so that they know that the 10mg pill they took today will not fully leave their system for 5+ days.

Liz

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