[Ellie]

Working hard, I promise!!

(Two times for the bump)

[Jaye]

Hi Ellie,

I just thought of something you might want to ask your doc about. You mentioned seizures connected with the withdrawal of caffeine. Surprisingly, researchers have found that people who drink coffee are somewhat less likely to develop Parkinson's Disease (PD), and that caffeine works on one kind of "A" receptor cells in the brain. They set about finding a drug for PD that would work on similar receptor cells, and sure enough, if you block the A2A receptors (name of the brain chemical or neurotransmitter is adenisone), the overall level of dopamine (which we lack) in the brain goes up. There's an experimental drug called istradefylline (or KW-6002 as its experimental name) which is an A2A receptor antagonist (blocker, sort of). I have been on istradefylline for about 2 years as a participanat in the clinical studies, and at least in my case, it has a moderately beneficial effect on my ability to move. I was thinking your doc might have a clue as to whether something like this would help you, and if not, maybe ask another neurologist.

Hmmm... I just searched PubMed ( www.pubmed.org ) on "A2A receptor antagonist and seizure" (without the quotes) and found several articles showing that they're trying out this type of drug on rats at NIH (National Institutes of Health). Also just googling on the same phrase yields some very interesting results.

Hope this is of interest.

Jaye

[ConsiderThis]

Originally Posted by Jaye

Hi Ellie,

I just thought of something you might want to ask your doc about. You mentioned seizures connected with the withdrawal of caffeine. Surprisingly, researchers have found that people who drink coffee are somewhat less likely to develop Parkinson's Disease (PD), and that caffeine works on one kind of "A" receptor cells in the brain. They set about finding a drug for PD that would work on similar receptor cells, and sure enough, if you block the A2A receptors (name of the brain chemical or neurotransmitter is adenisone), the overall level of dopamine (which we lack) in the brain goes up. There's an experimental drug called istradefylline (or KW-6002 as its experimental name) which is an A2A receptor antagonist (blocker, sort of). I have been on istradefylline for about 2 years as a participanat in the clinical studies, and at least in my case, it has a moderately beneficial effect on my ability to move. I was thinking your doc might have a clue as to whether something like this would help you, and if not, maybe ask another neurologist.

Hmmm... I just searched PubMed ( www.pubmed.org ) on "A2A receptor antagonist and seizure" (without the quotes) and found several articles showing that they're trying out this type of drug on rats at NIH (National Institutes of Health). Also just googling on the same phrase yields some very interesting results.

Hope this is of interest.

Jaye

Oh! This is such a brilliant post!!!!!
I wish you would post it under General. I think visitors who came here and read this post might be very happy with the new information.

Please woiuld you think about doing that?????

[Ellie]

Maybe we can kick up a clinical study thread? Post what we know and if anyone is involved.

[Jaye]

Originally Posted by ConsiderThis

Oh! This is such a brilliant post!!!!!
I wish you would post it under General. I think visitors who came here and read this post might be very happy with the new information.

Please woiuld you think about doing that?????

CT,

I have done as you suggested. Thanks. It's work, and this old work horse is getting very tired. I or someone should work up some lessons on how to find out medical things, I suppose, since it's been so useful in helping others and in keeping my docs on their toes (LOL, mine are the finest). Here are some suggestions to start with:

You can learn to use the public medical library (http://www.pubmedcentral.nih.gov/) with simple tutorials they have there for free. You can look up words in a medical dictionary at http://www.nlm.nih.gov/medlineplus/mplusdictionary.html.

Don't be medically in the dark. Learn and be in charge of your life (no one else is that into it, LOL).

I'm not in the medical field, but I can read.

Jaye

[ConsiderThis]

Originally Posted by Jaye

CT,

I have done as you suggested. Thanks. It's work, and this old work horse is getting very tired. I or someone should work up some lessons on how to find out medical things, I suppose, since it's been so useful in helping others and in keeping my docs on their toes (LOL, mine are the finest). Here are some suggestions to start with:

You can learn to use the public medical library (http://www.pubmedcentral.nih.gov/) with simple tutorials they have there for free. You can look up words in a medical dictionary at http://www.nlm.nih.gov/medlineplus/mplusdictionary.html.

Don't be medically in the dark. Learn and be in charge of your life (no one else is that into it, LOL).

I'm not in the medical field, but I can read.

Jaye

Thank you, Thank you, Thank you!!!!!

((((((((Jaye))))))))

What a great work horse you are!!!!!

But you don't seem like a horse to me, At All!

I hope you are feeling happy today! (((((((Jaye)))))))

[ConsiderThis]

I just sent out an eCard to people who have written to me after visiting my site...

here's a link if you want to take a look at the eCard...

http://www.americangreetings.com/vie...7&source=ag992

If anyone wants to use it, and wants me to change the Sender's Name, let me know.