Give me a little more time by tommorrow I will do a bit more research and I cant promise but i will try --today im in a rush. OK

Thank you. When you do get the time, go ahead and re-read that post and, again, give your reply of "yes, I can take a guess at this," or "no, I can't even begin to guess at this." You don't have to explain anything if you don't want to, but again, you can if you want.

As for now, go ahead and answer this new question I have first, then go back and re-read that other post and give an answer to that later. So here's my new question:

Now just from using common sense, if someone has chronic major depression in which those glucocorticoids are uncontrolled (in other words, the hypothalamus has failed in terms of regulating the glucocorticoids) and they are overworking and overworking a vast number of those pleasure neurons to death, wouldn't that mean that the rate of activity that the failing hypothalamus is using (gaining) in an attempt to regulate (stop) the glucocorticoids is less than the rate of loss of pleasure activity due to the glucocorticoids overworking and overworking a vast number of those pleasure neurons to death during chronic major depression (since the failing hypothalamus is using less activity in trying to stop the glucocorticoids)? Again, just from using common sense, wouldn't the loss of pleasure activity be greater?

Again, just a simple answer “yes, it does,” or “no, it does not work that way and we don't even know if there are moments (brief, a second or less or more or even for longer periods) during chronic major depression where the rate of loss of pleasure activity just due to the glucocorticoids overworking and overworking those pleasure neurons to death is greater than the rate of activity that the failing hypothalamus gains in an attempt to stop the glucocorticoids.” Again, you can just give a simple answer—you don't have to explain anything, but you can if you want.

Hi Matt
I really think this thread has run its course and just seems to be going in circles now.

It may be unrealistic to expect another member to answer these questions for you, although they are to be commended for trying! These are questions you should be asking qualified professionals, and even there, you may not get finite answers as there really are none!

It also is not really fair to try to tell another member exactly how they should answer...they can only answer in their own way.

So I am going to close this thread now.